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This lipid modification allows binding to albumin in the bloodstream
Goldstein et al
The most commonly reported effects include: Nausea, especially after starting treatment or increasing the dose Vomiting or stomach discomfort Diarrhea or constipation Reduced appetite and lower calorie intake For many people, these symptoms improve as the body adjusts over the first few weeks
According to the American Academy of Orthopaedic Surgeons, it may take several weeks to notice an improvement [2]
Such benefits occur only if patients tolerate the drug long enough to reach and maintain an effective exposure
While non-modifiable risks like age, gender, and genetics are well-known, emerging evidence underscores that obesity, metabolic syndrome, and gut dysbiosis are potent, modifiable risk factors, intricately linked to daily dietary patterns (8, 9)
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